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Co-immunoprecipitation mass spectrometry and CRISPR KO in cells identified that mitochondrial m -AAA protease AFG3L2 is responsible for degrading SLC25A39 through the matrix loop 1

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It is synthesized with structural modifications that extend its stability, and studied in preclinical and translational research involving amylin signaling, neuroendocrine regulation, and energy-balance pathways

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