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Critical distinction for prescribers: Category 1 reclassification does not mean FDA approval

The underlying pharmacological rationale for this specific tripartite combination relies on targeting multiple physiological bottlenecks simultaneously, thereby preventing the biological healing process from stalling at any single point of failure

doi: 10.1097/TP.0b013e3182911739 97 De Sousa-AmorimERevueltaIDiekmannFCofanFLozanoMCidJet al

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Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial
