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An estimated 1 of 88 individuals in the United States is affected with an autism spectrum disorder (ASD) [1]
The residues His48, Asp49, Tyr52, and Asp99 make up the active site, coordinating Ca 2+ by a hydrogen bond ( In human neuroblastoma SK-N-SH cells, notexin produces an increase in intracellular Ca 2+ and ROS levels, activating p38 MAPK/ATF-2 and JNK/c-Jun signaling pathways
medRxiv2026 May 19
