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Notably, this mitochondrial iron loading comes at the expense of cytosolic iron homeostasis, resulting in cytosolic iron deficiency and induction of the low iron IRPIRE response, suggesting that, as destinations for iron, mitochondria are hierarchically above other cellular compartments [101]

Verstreken, P

Neurochem Int 61, 11211132

2017 Feb 14;23(6):986-998

It's about your cells getting overloaded trying to process everything
