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This study explores a new source of immunogenic polypeptides originating from a nonconventional open reading frame within human insulin mRNA, which can be targeted by cytotoxic CD8 + T cells present in individuals with T1D, potentially contributing to -cell destruction in the disease

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mTORC1 upregulation leads to accumulation of the oncometabolite fumarate in a mouse model of renal cell carcinoma

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