is part of the antioxidant glutathione peroxidase Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification The Selenoprotein Glutathione Peroxidase 4:

Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo Am J Respir Cell Mol Biol 1999 20 : 189198 Hwang S, Ding A

However, the presence of conserved amino acids in the shared motif between Zot and zonulin lead these researchers to synthesize an octapeptide, now known as LA, with the same amino acid sequence as the NH 2 -terminus of human fetal zonulin, positions 815 (7)

doi: 10.1016/J.RVSC.2011.11.008 126 TriantaphyllopoulosK

doi: 10.1056/NEJMoa1005361

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