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doi: 10.3892/br.2015.462 114 DiehlFSchmidtKChotiMARomansKGoodmanSLiMet al

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394,395 As mentioned above, HSF1 is subject to numerous PTMs that govern its activation or inhibition at different levels, and the mediators of these PTMs themselves, or their upstream receptors or sensors, help integrate multiple different stimuli in the HSF1-mediated response

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This section will detail the key mechanisms of ferroptosis, including iron overload, lipid peroxidation and the dysregulation of the antioxidant system (particularly the system XcGPX4 pathway), highlighting their interactions that culminate in cell death and tissue damage (Fig

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