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CK-MB, MB isoenzyme of creatine kinase

383 Moreover, we also found that bromodomain containing 4 (BRD4) is upregulated in ICB-resistant melanoma patients, and inhibiting BRD4/AKR1C2 axis by bromodomain and extra-terminal motif (BET) inhibitors has been shown to enhance the susceptibility of melanoma to ferroptosis and immunotherapy

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Another possible explanation for the enhanced permeation of CS-EXE-GEN-LIPO in comparison with EXE-GEN-LIPO is that encapsulation of drugs in the chitosan-coated liposomes makes it unavailable for the P-gp pump and therefore, it can be easily transported across the intestinal wall for absorption
