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& Geisslinger, G

In leptin-deficient obese mice, CB1-expressing presynaptic neurons change from glutamatergic to predominantly GABAergic in the lateral hypothalamic area, and because CB1 is associated with G i/o protein, this remodeling results in increased orexin-A, an orexigenic peptide (Cristino et al., 2013)

Some preliminary research also suggests citicoline could help people with alcohol , cannabis and food addiction (10)