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The activation of the NLRP3 inflammasome and subsequent release of IL-1 and IL-18 are triggered by innate immune cells like macrophages and dendritic cells, which recognize danger signals and respond by initiating the inflammatory response

doi: 10.1038/s41586-019-1705-2 136 DollSFreitasFPShahRAldrovandiMda SilvaMCIngoldIet al

Nature 436 , 112116 (2005)

They concluded that ALC has positive therapeutic effects on the reproductive axis in hypogonadotropic women with FHA and improves the condition by acting through the HPG axis [17]

For example, iodine from foods and supplements is processed by the thyroid gland so that the body can properly use it