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The mechanisms involved include mitochondrial and endoplasmic reticulum stress, leading to oocyte apoptosis and autophagy, disruption of the cytoskeletal structure, and a reduction in the extrusion rate of the PB1 (Zhai et al., 2018

Nevertheless, regardless of the certain background of primary HT, the common feature of pathological findings in the thyroid gland is its lymphocytic infiltration

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Additionally, the disruption of electron flow in the respiratory chain due to an impaired mitochondrial respiration also leads to a reduced reoxidation of NADH into NAD+, thereby reducing oxidation of pyruvate by the pyruvate dehydrogenase complex