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Mitochondrial dysfunction in liver diseases Mitochondria are critical sites of bioenergetics, fat oxidation, intermediary metabolism, apoptosis, mitophagy, and redox homeostasis [90,91,92,93]

doi: 10.3390/ph14080717

Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells

Shuyan Chi: Writing review & editing, Project administration, Conceptualization

Within cells (principally the liver where it is stored) the folic acid found in enriched food and in vitamin supplements is converted first to dihydrofolate (DHF) and then to tetrahydrofolate (THF also H 4 folate) through the action of dihydrofolate reductase, an NADPH-requiring enzyme