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10.1016/j.plaphy.2024.109471 146 PungleR.NileS
Cellular GSH reserves can be depleted in at least three different waysby increasing GSH oxidation, by inhibition of biosynthesis, or by inactivation of the genes encoding the enzymes of GSH synthesis
The enzymatic function of GAD65 and subsequent regulation of GABA production is dependent on a key residue within the catalytic loop, Lys396 [2]
BioNanoScience 15, 351
During the latter, GSH acts as a reducing agent and donates an electron in the presence of the enzyme glutathione peroxidase (GPx), thereby giving rise to its oxidized form, GSSG (Higuchi, 2014)
