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In humans, a study on a cohort of 49 healthy elderly subjects reported that the subjects maintained on a regimen of dietary restriction, in comparison to subjects maintained on ab libitum diet, exhibited enhanced verbal memory, albeit without increased serum levels of BDNF [182]
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In monocytes and macrophages, caspase-1 activates caspases-3/7 and induces apoptosis in the absence of GSDMD while caspases-3/7 specifically block pyroptosis by cleaving GSDMD during apoptosis, which is called bidirectional crosstalk [169]
doi: 10.1016/j.molp.2025.08.004 35 RajkumarMSTembhareKGargRJainM
"Hemoglobinopathies"
