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MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)

DECLARATIONS Ethics approval and consent to participate This study does not involve human data or tissue This study involves animals o All animal experiments in this study are approved by Animal Subjects Ethics Sub-committee (ASESC), Research Committee, The Hong Kong Polytechnic University with ASESC reference number 19-20/6-HTI-R-HMRF Consent for publication Not applicable Availability of data and material The datasets during and/or analyzed during the current study available from the corresponding author on reasonable request

By restoring optimal B12 levels, these injections help support metabolism , enhance mental clarity and mood , and promote sustained energy throughout the day

When an article on MTHFR mentions compound heterozygous, it refers to having one copy of the MTHFR C677T variant and one copy of the A1298C variant

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