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Collectively, these findings support that GHS-R is essential for ghrelin-induced excitation of AgRP/NPY neurons, but not for ghrelin-induced suppression of POMC

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 10% by weight of the poloxamer

This intracellular accumulation of FFAs and their esterified products, such as diacylglycerols and triglycerides, initiates lipotoxicity

Li W, Zeng Q, Liu Y, Zhao X, Chen X, Yang W
