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furosemide) can increase urinary excretion of thiamine and thereby lower B levels over time

doi: 10.1016/j.ejphar.2014.08.001 [DOI] [PubMed] [Google Scholar] 29.Jimnez-Andrade JM, Ortiz MI, Prez-Urizar J, Aguirre-Bauelos P, Granados-Soto V, Castaeda-Hernndez G

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That action spares nicotinamide for NAD+ production and preserves SAM, which in cell and animal studies translates to reduced fat storage, smaller fat cells, and higher cellular energy output

While oral supplements must navigate the complex digestive processwhere absorption can drop as low as 1-2% for some individualsinjections deliver the full dose directly into your system