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Toxicity outcomes vary based on particle characteristics (type, size, and surface chemistry), exposure dose and duration, organismal factors (age, sex, species), and co-exposure to other pollutants

System xc serves as an amino acid reverse transporter that orchestrates the exchange of extracellular cystine and intracellular glutamate across the cell membrane [77]

It helps in the breakdown and elimination of toxins and harmful substances

Further supporting global heterogeneity, a 2024 metaanalysis published in Nature reported PD prevalence estimates ranging from 49 per 100,000 in SubSaharan Africa to 1081 per 100,000 in Latin America [39], figures that suggest even greater regional variability than captured in GBD estimates

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