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As with most RTKs, IGF-1R acts as a node in a complex web of robust signaling networks [72, 73]
(2020) discovered that DHA inhibited the expression of PRIM2, leading to the downregulation of SLC7A11 and -catenin, key regulators of ferroptosis in lung cancer cells
2020;33:e14515
MDM2 inhibitors, including Nutlin-3, APG-115, RG7388, DS-3032, and MK-8242, suppress the p53-MDM2 interaction, stabilizing p53 and inducing apoptosis in malignancies such as gastric cancer and leukemia (Ding et al., 2013
