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Mutations in the MBD of MECP2, affecting its DNA-binding affinity, can be classified into three categories: those causing significant reduction (e.g., L110V, S134C, P152R, D156E), moderate increase (e.g., A140V, R111G), and minimal or slight effects (e.g., F155S, R106Q, R106W, R133C, R133H) on MECP2s DNA-binding affinity (34, 106, 107)

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Nrf2ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

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doi: 10.1128/microbiolspec.mchd-0034-2016 93 KazatchkineMDFearonDT