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What the potency comparisons actually showed In the classic anabolic studies, IGF analogs with reduced IGFBP binding including Long R3 IGF-1 produced greater nitrogen retention, greater gut and organ growth, and more pronounced anabolic responses than equimolar native IGF-1 in rodents, particularly in catabolic states such as dexamethasone treatment or dietary restriction

Notably, GSH depletion did not further decrease lipid accumulation in these knockdown conditions, indicating a lack of additive effect