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This also indicates a role of APLN/APLNR signaling in the regulation of immunological processes, which needs to be further investigated

2024;9:e172632

A meta-analysis of 10 trials demonstrated that PRP provided better pain reduction than corticosteroids at 3, 6, and 12 months post-injection (PMID: 31925218)

However, these mechanisms remain under active investigation and have not been fully characterized

Individuals with R116Q mutations in the PNPO gene have a milder phenotype, with some experiencing no seizures or late-onset symptoms and only mild to moderate mental retardation [36]
