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Description
Dopaminergic SN cells are usually pigmented with black neuromelanin, produced from of the autoxidation [57] or enzyme-mediated oxidation [58] of the cytoplasmic dopamine (DA) to DA-o-quinone, which then Polymerizes
Interruption of BCAA homeostasis by genetic or pharmacological inhibition of the BCKDH complex could affect insulin secretion and sensitivity (Shin et al., 2014
: PI3K/Akt, GSK-3 -
The absence of a bulky aromatic group wedging into subsite B could be the reason for the lowered transport inhibition observed in milnacipran in comparison to duloxetine (Supplementary Table 2)
10.1021/bi901846y
