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Potential muscle-related benefits: Increased appetite (helpful in calorie-surplus phases) Elevated growth hormone Possible preservation of lean mass In a two-year randomized, placebo-controlled trial of the oral ghrelin mimetic MK-677 in older adults, daily dosing significantly increased pulsatile growth hormone and IGF-1 levels to those of younger adults and increased fat-free mass versus placebo, suggesting enhanced protein-accruing pathways that could help preserve lean body mass

Autocrine prostaglandin E2 signaling promotes promonocytic leukemia cell survival via COX-2 expression and MAPK pathway

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10.1371/journal.pone.0032621 69 DenningD

*Correspondence: Jeffrey P