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Understanding these metabolic reprogramming processessuch as PDK4-mediated pyruvate dehydrogenase inhibition and PKM2/PKM1 isoform switchingcould identify novel therapeutic targets by regulating key pathways like Anaphase-promoting complex/cyclosome and its coactivator Cdh1 (APC/C-Cdh1)-dependent PFKFB3 stabilization or pentose phosphate pathway activation

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However, it comes at the cost of reduced efficiency in ATP production

107 World Health Organization (2020b)

(1993) Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans