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Modulators of hepatic energy, metabolic, lipid homeostasis, immune and inflammatory response (PPARA, RXRA, PXR) have a significantly higher expression in GF-HLCs and PHHs in comparison to SM-HLCs (Figure 2F)

Cholangiocytes possess an innate immune system consisting of Toll-like receptors (TLRs) and constantly interact with pathogen-associated molecular patterns (PAMPs, including LPS and other antigens), which circulate from the gut 50

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The same review also examined two Phase II clinical trials involving patients with ulcers

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