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Glutaredoxins Glutaredoxins (Grx) are the glutathione-dependent enzymes that catalyze the inter-conversion of soluble thiols and disulfides (trans-sulfuration) and the transfer of glutathione, cysteine, homocysteine and cysteamine groups to protein cysteines and from thiolated cysteines, as part of the biological control mechanisms

49,71,72 Hence, targeting the Chac2GSH signaling axis offers a promising strategy for precise intervention in neutrophil pathogenic activation, thereby providing a novel therapeutic avenue for mitigating periodontitis-associated systemic inflammatory responses

Propionic acidemia is an autosomal recessive disorder that results from mutations in either of the two genes encoding the subunits of the mitochondrial enzyme, propionyl-CoA carboxylase (PCC)