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[77] compared the metabolic profile of CD patients intestinal mucosa (relative to the disease controls), blood plasma, and urine (relative to the healthy controls) samples using NMR spectroscopy and multivariate analysis and observed the changes in Pro, arginine (Arg), glycine (Gly), histidine (His), glutamate (Glu), aspartate (Asp), tryptophan (Trp), fumarate, formate, succinate (Succ), glycerophosphocholine (GPC) and allantoin (Alln) in the small intestinal mucosa and changes in Pro, Arg, Gly, alanine, Glu, Gln, glucose (Glc), lactate (Lac), acetate (Ace), acetoacetate (AcAc), -hydroxybutyrate (-OHB), pyruvate (Pyr), Succ, citrate (Cit), choline (Cho), creatine (Cr), phosphocreatine (PCr) and creatinine in blood plasma and changes in Pro, Trp, -OHB, Pyr, Succ, N-methylnicotinamide (NMN), aminohippurate (AHA), indoxyl sulfate (IS), and Alln in urine samples of CD patients [77]

Total body composition was determined by a whole-body scan on a dual-energy x-ray absorptiometry device (DXA) (Horizon A DXA System, Hologic Inc, Marlborough, MA, USA)

Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, Didonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL

Recommended Dose Adults (18 Years): Take 3 capsules 2 times per day