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COPD COPD is a polygenic disease with a significant epigenetic component, that there are multiple environmental risk factors (including smoking and many others) that interact and accumulate through life in complex ways, hence modulating organ development, maintenance, repair, and aging and eventually determining a range of potential lung function trajectories through life and the occurrence of early multimorbidity and premature death (Cavaills et al
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V.McKayS
Diabetes Care 31, S185S189
This then results in recirculating oestrogen, now in excess as new oestrogen has been produced by the body
