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Interestingly, repeated OS can initiate and maintain elevated levels of IL-1, leading to a positive feedback loop between OS and neuroinflammatory [104]

Environmental factors, such as pH, temperature, and interactions with other ingredients in the formulation, can also impact their stability and functionality [12]

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In OHP-treated male mice, significant mechanical allodynia was accompanied by an increased circulating cluster of differentiation 4 receptors (CD4 + ) and cluster of differentiation 8 receptors (CD8 + ) T-cells [84]

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