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PAK-CRIB-binding to Rac/Rop suppresses the intrinsic and catalytic rates of GTP hydrolysis of Rac/Rop that make it possible to purify the active constitutively active (CA) form but not the inactive dominant negative (DN) form of OsRac1 from cell lysates

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Dosing Protocol The parallel escalation used in the REDEFINE trials, converted to U-100 units at 10 mg/mL total (5 mg/mL of each component)