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Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke

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However, a consensus definition from an expert committee defines an exacerbation as a patient experiencing the worsening of 3 or more of these symptoms over 48 hours, requiring a change in treatment 14 : Cough Fatigue and/or malaise Breathlessness and/or exercise intolerance Hemoptysis Sputum volume and/or consistency Sputum purulence Expert commentary: The impact of exacerbations on patients with bronchiectasis Speakers: Mark Metersky, MD