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This work suggests that HGF-MET may also protect from parthanatos, a form of caspase-independent regulated cell death occurring especially in neurons and driven by PARP1 hyperactivation ( Oxidative DNA stress occurring after cerebral ischemia is associated with a decrease in apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) expression (Niimura et al., 2006c)

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