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The plate was incubated for further 30 min at 37 C without CO 2 for equilibration and then inserted into a Seahorse XFe96 Analyzer (Agilent Technologies) loaded with a hydrated cartridge, for measurement

Mitochondrial biogenesis and clearance: a balancing act
Variants in the VEGF gene may alter its binding affinity to receptors or its expression levels, impacting endothelial cell proliferation and angiogenesis in DR (Sim et al., 2014

However, those models used in reproductive toxicology based on QSAR methodology to estimate the extent of transfer of xenobiotics may not always be so reliable since they accept that the transport of drugs and chemicals through the placental barrier occurs only by passive diffusion and not by active transport [102,103,104,105,106,107,136,137]

A similar situation was observed in genetic models of ovarian cancer tumor-initiating cells, suggesting that tumor cell intracellular iron levels are also elevated in the early stages of ovarian cancer
