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In addition, drugs prescribed against particular diseases are often associated with poor solubility, instability, lack of selectivity, and undesirable side effects

4.6 VEGF inhibitors reducing angiogenesis-driven hypoxia GBM tumors tend to be poorly perfused as a result of their dysfunctional and abnormal vasculature, paradoxically contributing to an aggressive cycle of hypoxia it tries to alleviate with angiogenesis (157, 163)

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[DOI] [PubMed] [Google Scholar] 467.Katsuyama H., Otsuki T., Tomita M., Fukunaga M., Fukunaga T., Suzuki N., Saijoh K., Fushimi S., Sunami S

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