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It has been shown to inhibit the NLRP3 inflammasome, a multiprotein complex responsible for the activation of highly inflammatory cytokines like IL-1 and IL-18

Controlled clinical and biopsy-level evidence for topical ascorbic acid is among the strongest in cosmetic dermatology

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Patients treated with a mixture of combined metabolic activators (CMAs) consisting of glutathione and NAD + precursors, in placebo-controlled, open-label phase 2 study and double-blinded phase 3 clinical trials, showed shorter time to complete symptom-free recovery and improved plasma biochemical parameters associated with inflammation and antioxidant metabolism [164]

In: Goodman & Gilman's Pharmacological Basis of Therapeutics