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despite the availability of these new agents, metformin continues to be the first-line agent for most patients with T2DM [24], with the notable exclusion of patients with heart failure

Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase: regulation by insulin, cyclic AMP and pyruvate

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Our results showed that APP treatment significantly increased the serum GSH level and GSH/GSSG ratio, suggesting the enhanced antioxidant capacity of the APP-treated serum