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doi: 10.1016/j.neures.2006.01.002

This facilitates transmembrane flow of Na + , K + , and Ca 2+ , inducing cell membrane depolarization and activating downstream signaling cascades (Figure 2) ( 4 2 receptors are widely distributed in the VTA, NAc, and prefrontal cortex, playing a central role in regulating dopamine release and reinforcement learning ( 7 receptors are primarily localized in dopaminergic neurons and participate in modulating long-term potentiation of glutamatergic neurons ( 4 2 and 6 2 3 complexes

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A molecule that fits perfectly into GLP-1 receptors might not activate GIP receptors effectively, and vice versa