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Tamoxifen, an estrogen blocker, is effective in treating recent-onset and tender gynecomastia (after stopping or switching spironolactone) when administered at doses of 1020 mg twice daily

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Additional information EMBO Mol Med (2021) 13: e14323

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To mitigate any potential negative effects on methylation, additional interventions can support the methyl cycle while using folinic acid therapy: Improving SAH (S-adenosylhomocysteine) levels by reducing homocysteine through methyl donors like betaine (TMG), vitamin B6 (P5P), and methylcobalamin (B12)