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Does Lipoic Acid Consumption Affect the Cytokine Profile in Multiple Sclerosis Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

That is, it was shown that HSP70, proteins with pronounced neuroprotective properties, in conditions of ischemia mobilize antioxidant resources in neurons, in particular, increase the level of both cytosolic and mitochondrial glutathione, which prevents the development of oxidative stress (Pavlov et al., 2017a)

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Peroxisome proliferators activator receptors gamma (PPAR) has been reported to effectively suppress cancer progression.132 When treated with Keap1 shRNA, PPAR of the nonsmall cell lung cancer (NSCLC) cells increase, and cells were more susceptible to arsenic trioxide, etoposide, and doxorubicin, suggesting that Nrf2 contributes to drug resistance by the downregulation of PPAR.133 To summarize, when Nrf2 is overactivated in cancer cells, specific antioxidant enzymes, phase II enzymes, and transporters are excessively expressed