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Of a particular interest, poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polyester, which is used in several FDA-approved products in the form of microspheres and other pharmaceutical dosage forms 2,3

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Macrocyclic lactone Rapamycin, a macrocyclic lactone isolated from Streptomyces hygroscopicus , is known for its immunosuppressive and antimicrobial properties due to its ability to inhibit the mTOR pathway, thereby promoting autophagy [63]

This growing focus is attributable to its broad-spectrum biological activities, including anti-inflammatory, antioxidative, immunomodulatory, neuroprotective, antiproliferative, antibacterial, and anticancer effects (34)