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This balance is maintained by antioxidants including glutathione

Oxidant damage to cells will give rise to a cascade of proinflammatory effects by the production of lipid peroxides

Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)

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Moreover, in vitro studies and animal models suggest that cigarette smoke may interfere with the local antiinflammatory effects of vitamin D (20, 21)