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For glutathione, timing can influence how well the supplement works alongside your body's natural rhythms

doi: 10.1038/35038090

& De Sanctis, V

Psychiatry 66 , 10731074 (2005)

Melatonin, known for its antioxidant properties, also modulates the Nrf2 pathway, enhancing the expression of heme oxygenase-1 (HO-1), which strengthens antioxidant defenses in DN (Negi et al., 2011a)