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A 2020 meta-analysis of five randomized controlled trials (RCTs) encompassing 334 NAFLD patients confirmed that L-carnitine supplementation significantly improves insulin sensitivity (58)

[177] [178] However, large doses of amphetamine may indirectly cause dopaminergic neurotoxicity as a result of hyperpyrexia, the excessive formation of reactive oxygen species, and increased autoxidation of dopamine

Female fertility may also be affected by L-carnitine

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Chronic inflammatory activity is decisive in determining disease progression and the pathophysiological base of fatigue (Giovannoni et al., 2022)
