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Description
Endogenous thiamine levels increase in response to multiple stresses such as salinity or cold, possibly due to its need as a cofactor, as thiamine pyrophosphate is a required co-enzyme for several reactions of central metabolism

10.1371/journal.pmed.1000097 37 NIHR (2025)

Also reduce heavy metal toxicity and support methylation in general to promote SAMe

S.GodburnK

What is synergy
