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They sold the San Francisco-based company in 2020 to a similar firm called Ethos Preparedness

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The mechanistic difference translates directly to side-effect profiles: cagrilintide causes nausea and vomiting in 3040% of subjects during dose titration (similar to GLP-1 agonists), while tesofensine produces insomnia, dry mouth, and increased heart rate in 2035% due to its sympathomimetic effects

In terms of cellular components, significant enrichment was observed in collagen-containing ECM, basement membrane, and endoplasmic reticulum lumen