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Phytoestrogens from Siberian rhubarb have been shown to preferentially activate ER-beta, with a significantly weaker effect on ER-alpha, indicating its probable safety in breast and endometrial tissues

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The Ca 2+ -calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)5-AMP-activated protein kinase (AMPK) signaling cascade pathway can be triggered by ROS produced by TH-mediated oxidative phosphorylation, which can facilitate the autophagy of damaged mitochondria and ultimately increase the overall quantity of mitochondria