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The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial

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BPD Bronchopulmonary dysplasia OS Oxidative stress NICHD The National Institute of Child Health and Human Development ES Endoplasmic reticulum stress UPR Unfolded protein response VEGF Vascular endothelial growth factor MSC Mesenchymal stem cells Nrf2 Nuclear erythroid-E2-related factor 2 ARE Antioxidant reaction elements HO-1 Heme oxygenase-1 SIRT1 Silent mating-type information regulation 2 homolog 1 NAD Nicotinamide adenosine dinucleotide SENP1 Small ubiquitin-like modifier (SUMO)-specific protease 1 PBMC Peripheral blood mononuclear cells PPAR Peroxy-proliferator-activated receptor AT2 Primary alveolar type 2 cells TXN Thioredoxin TXNRD Thioredoxin reductase ATG Aurothioglucose NF-B Nuclear factor B Tet Tetralin ISAPP The International Scientific Association for Probiotics and Prebiotics 2-FL 2-fucosyllactose LNnT Lacto-N-neotetraose 3-GL 3-galactosyl lactose HMO Human milk oligosaccharides DPPH, 2 2-diphenyl-1-hydrazide SCFA Short chain fatty acids SOD Superoxide dismutase GSH-Px Glutathione peroxidase NQO1 NAD (P)H:quinone oxidoreductase

The absence of FDA approval means no verified manufacturing standards, dosing protocols, or safety benchmarks exist for human use

There are mainly two unresolved issues in the nanomedicine area