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In the context of aging research, NAD+ occupies a position of particular scientific significance: research consistently demonstrates that NAD+ levels decline substantially with age in mammalian tissues, and that this decline correlates with hallmarks of biological aging including mitochondrial dysfunction, impaired DNA repair, and metabolic dysregulation

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In the liver, Lgr5 -positive cells only appear after damage when they regenerate hepatocytes and bile ducts (Huch et al., 2013b)

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Many modifications of the 45S5 have followed