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In preclinical studies of COX-2 selective inhibitors, suppression of PGE2 at the inflammatory site with no change in serum TXB2 confirms COX-2 selectivity, while suppression of both indicates non-selective COX inhibition

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It has also been claimed that picroliv exerts choleretic action [180]

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Much faster release was seen at pH 5 due to protonation of -COOH groups and increased solubility of DOX at lower pH